Phonological Units in Spoken Word Production: Insights from Cantonese

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An effective placement method for the single container loading problem

© 2016 Elsevier Ltd. All rights reserved. This study investigates a three-dimensional single container loading problem, which aims to pack a given set of unequal-size rectangular boxes into a single container such that the length of the occupied space in the container is minimized. Motivated by the practical logistics instances in literature, the problem under study is formulated as a zero-one mixed integer linear programming model. Due to the NP-hardness of the studied problem, a simple but effective loading placement heuristic is proposed for solving large-size instances. The experimental results demonstrate that the developed heuristic is capable of solving the instances with more than two hundred boxes and more efficient than the state-of-the-art mixed integer linear program and existing heuristic methods

Inactivation of Dicer1 in Steroidogenic factor 1-positive cells reveals tissue-specific requirement for Dicer1 in adrenal, testis, and ovary

<p>Abstract</p> <p>Background</p> <p>The synthesis of microRNA (miRNA) is a multi-step process that requires the action of the ribonuclease Dicer1. Dicer1 is responsible for the final processing of miRNA and has been implicated in cellular processes such as proliferation, apoptosis, and differentiation. Mouse embryos lacking <it>Dicer1 </it>die in early embryogenesis. In this study, we investigated whether <it>Dicer1 </it>is required for development of adrenal, testis, and ovary in mouse embryos.</p> <p>Results</p> <p>To target <it>Dicer1 </it>deletion specifically in developing adrenals and gonads, we used Steroidogenic factor 1-cre (<it>Sf1/Cre</it>) line in which Cre recombinase is active in the progenitor cells of adrenals and gonads. Lack of <it>Dicer1 </it>in the SF1-positive cells did not affect formation and early differentiation of the adrenals and gonads. However, increasing numbers of apoptotic cells were first detected in the <it>Dicer1 </it>knockout adrenal cortex at 18.5 days post coitum (dpc), followed by apoptosis of somatic cells and germ cells in the testis at postnatal day 0. Affected adrenal and testes underwent complete degeneration 48 hrs after the onset of apoptosis. However, ovaries were not affected at least until postnatal day 5, when the animals died due to adrenal insufficiency.</p> <p>Conclusions</p> <p><it>Dicer1 </it>is dispensable for formation and differentiation of fetal tissues derived from the SF1-positive adrenogonadal primordium. <it>Dicer1 </it>is essential for maintaining cell survival in adrenal and testis; however, development of the ovary from fetal stages to postnatal day 5 does not require the presence of <it>Dicer1</it>. Our results reveal a tissue-specific requirement of <it>Dicer1 </it>and microRNAs. Future research is needed to understand how the tissue-specific role of <it>Dicer1 </it>is established.</p

Progenitor-like cells derived from mouse kidney protect against renal fibrosis in a remnant kidney model via decreased endothelial mesenchymal transition

Showing A quantification of GFP-positive cells in the lung after intravenous injection of MKPCs in five-sixths nephrectomized mice (y axis shows the number of cells, while the x axis (FL1-H) shows the fluorescence intensity; M1 is the area of GFP-positive cells) and B immunohistochemistry of the lung after intravenous injection of MKPCs into a mouse that underwent five-sixths nephrectomy. Few GFP positive cells were found in the lung at the first day but there were no GFP-positive cells at week 14. (TIFF 2253 kb

Sample entropy analysis of EEG signals via artificial neural networks to model patients' consciousness level based on anesthesiologists experience.

Electroencephalogram (EEG) signals, as it can express the human brain's activities and reflect awareness, have been widely used in many research and medical equipment to build a noninvasive monitoring index to the depth of anesthesia (DOA). Bispectral (BIS) index monitor is one of the famous and important indicators for anesthesiologists primarily using EEG signals when assessing the DOA. In this study, an attempt is made to build a new indicator using EEG signals to provide a more valuable reference to the DOA for clinical researchers. The EEG signals are collected from patients under anesthetic surgery which are filtered using multivariate empirical mode decomposition (MEMD) method and analyzed using sample entropy (SampEn) analysis. The calculated signals from SampEn are utilized to train an artificial neural network (ANN) model through using expert assessment of consciousness level (EACL) which is assessed by experienced anesthesiologists as the target to train, validate, and test the ANN. The results that are achieved using the proposed system are compared to BIS index. The proposed system results show that it is not only having similar characteristic to BIS index but also more close to experienced anesthesiologists which illustrates the consciousness level and reflects the DOA successfully.This research is supported by the Center forDynamical Biomarkers and Translational Medicine, National Central University, Taiwan, which is sponsored by Ministry of Science and Technology (Grant no. MOST103-2911-I-008-001). Also, it is supported by National Chung-Shan Institute of Science & Technology in Taiwan (Grant nos. CSIST-095-V301 and CSIST-095-V302)

Visual Similarity Perception of Directed Acyclic Graphs: A Study on Influencing Factors

While visual comparison of directed acyclic graphs (DAGs) is commonly encountered in various disciplines (e.g., finance, biology), knowledge about humans' perception of graph similarity is currently quite limited. By graph similarity perception we mean how humans perceive commonalities and differences in graphs and herewith come to a similarity judgment. As a step toward filling this gap the study reported in this paper strives to identify factors which influence the similarity perception of DAGs. In particular, we conducted a card-sorting study employing a qualitative and quantitative analysis approach to identify 1) groups of DAGs that are perceived as similar by the participants and 2) the reasons behind their choice of groups. Our results suggest that similarity is mainly influenced by the number of levels, the number of nodes on a level, and the overall shape of the graph.Comment: Graph Drawing 2017 - arXiv Version; Keywords: Graphs, Perception, Similarity, Comparison, Visualizatio

Electromagnetic emissions from the IC packaging

The EMC and EMI of the IC packaging are becoming increasingly important to modern electronics. Its EMC, SI, and PI have been broadly attested. But electromagnetic radiations from IC packaging and the corresponding EMI were seldom studied. In this paper, the fundamental principles and properties of the electromagnetic radiations caused by vias and traces in IC packagings are carefully investigated. Various radiation mechanisms are analyzed for different representative scenarios. Numerical simulations are employed to support the analyzing results. © 2012 IEEE.published_or_final_versio

Electromagnetic emissions from the IC packaging

The EMC and EMI of the IC packaging are becoming increasingly important to modern electronics. Its EMC, SI, and PI have been broadly attested. But electromagnetic radiations from IC packaging and the corresponding EMI were seldom studied. In this paper, the fundamental principles and properties of the electromagnetic radiations caused by vias and traces in IC packagings are carefully investigated. Various radiation mechanisms are analyzed for different representative scenarios. Numerical simulations are employed to support the analyzing results. © 2012 IEEE.published_or_final_versio